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The joint effect of the endothelin receptor B gene (EDNRB) polymorphism rs10507875 and nitric oxide synthase 3 gene (NOS3) polymorphism rs869109213 in Slovenian patients with type 2 diabetes mellitus and diabetic retinopathy.
Bregar D, Cilenšek I, Mankoč S, Reschner A, Petrovič D, Globočnik Petrovič M. Bregar D, et al. Bosn J Basic Med Sci. 2018 Feb 20;18(1):80-86. doi: 10.17305/bjbms.2017.2244. Bosn J Basic Med Sci. 2018. PMID: 28817788 Free PMC article.
The aim of the study was to evaluate the association of rs10507875 and rs869109213 (alone or in interaction) with diabetic retinopathy (DR) in subjects with type 2 diabetes mellitus (T2DM). We genotyped the single nucleotide polymorphism rs10507875 of the endothelin …
The aim of the study was to evaluate the association of rs10507875 and rs869109213 (alone or in interaction) with diabetic retinopathy (DR) …
[Mechanism of Astragali Radix-Coptis Rhizoma pair in treating type 2 diabetes mellitus based on network pharmacology].
Fu JY, Zhang Y. Fu JY, et al. Zhongguo Zhong Yao Za Zhi. 2021 Sep;46(18):4808-4815. doi: 10.19540/j.cnki.cjcmm.20210609.705. Zhongguo Zhong Yao Za Zhi. 2021. PMID: 34581092 Chinese.
This study aims to explore the main mechanism of Astragali Radix-Coptis Rhizoma pair(hereinafter referred to as the pair) in the treatment of type 2 diabetes mellitus(T2 DM) based on network pharmacology and animal experiment. ...The result showed that pair can be u …
This study aims to explore the main mechanism of Astragali Radix-Coptis Rhizoma pair(hereinafter referred to as the pair) in the treatment o …
Liver fibrosis associated with adipose tissue and liver inflammation in an obesity model.
Setyaningsih WAW, Sari DCR, Romi MM, Arfian N. Setyaningsih WAW, et al. Med J Malaysia. 2021 May;76(3):304-310. Med J Malaysia. 2021. PMID: 34031327 Free article.
INTRODUCTION: Obesity, the main risk factor for type 2 diabetes mellitus (T2DM), affects the secretion of various hormones that lead to change in metabolism. ...Increased BMI was followed by upregulation of proinflammatory mediators (MCP-1, CD68, TLR4, and NFkappaB) …
INTRODUCTION: Obesity, the main risk factor for type 2 diabetes mellitus (T2DM), affects the secretion of various hormones tha …
Correlation between renin-angiotensin system (RAS) related genes, type 2 diabetes, and cancer: Insights from metanalysis of transcriptomics data.
Pereira LX, Alves da Silva LC, de Oliveira Feitosa A, Santos Ferreira RJ, Fernandes Duarte AK, da Conceição V, de Sales Marques C, Barros Ferreira Rodrigues AK, Del Vechio Koike B, Cavalcante de Queiroz A, Guimaraes TA, Freire de Souza CD, Alberto de Carvalho Fraga C. Pereira LX, et al. Mol Cell Endocrinol. 2019 Aug 1;493:110455. doi: 10.1016/j.mce.2019.110455. Epub 2019 May 28. Mol Cell Endocrinol. 2019. PMID: 31145933
Although studies have provided significant evidence about the role of RAS in mediating cancer risk in type 2 diabetes mellitus (DM), conclusions about the central molecular mechanisms underlying this disease remain to be reached, because this type of information req …
Although studies have provided significant evidence about the role of RAS in mediating cancer risk in type 2 diabetes mellitus …
Diabetes-related sex differences in the brain endothelin system following ischemia in vivo and in human brain endothelial cells in vitro.
Abdul Y, Li W, Vargas JD, Grant E, He L, Jamil S, Ergul A. Abdul Y, et al. Can J Physiol Pharmacol. 2020 Sep;98(9):587-595. doi: 10.1139/cjpp-2019-0630. Epub 2020 Aug 20. Can J Physiol Pharmacol. 2020. PMID: 32496159 Free PMC article.
The endothelin (ET) system has been implicated to contribute to the pathophysiology of cognitive impairment and stroke in experimental diabetes. Our goals were to test the hypotheses that (1) circulating and (or) periinfarct ET-1 levels are elevated after stroke in both se …
The endothelin (ET) system has been implicated to contribute to the pathophysiology of cognitive impairment and stroke in experimental di …
Biomarkers for Diabetic Retinopathy - Could Endothelin 2 Be Part of the Answer?
Binz N, Rakoczy EP, Ali Rahman IS, Vagaja NN, Lai CM. Binz N, et al. PLoS One. 2016 Aug 2;11(8):e0160442. doi: 10.1371/journal.pone.0160442. eCollection 2016. PLoS One. 2016. PMID: 27482904 Free PMC article.
MATERIALS AND METHODS: Edn2 and Ednrb mRNA and Edn2 protein expression were assessed in young (8wk) and mature (24wk) C57Bl/6 (wild type; wt), Kimba (model of retinal neovascularisation, RNV), Akita (Type 1 diabetes; T1D) and Akimba mice (T1D plus RNV) by qRT-PCR an …
MATERIALS AND METHODS: Edn2 and Ednrb mRNA and Edn2 protein expression were assessed in young (8wk) and mature (24wk) C57Bl/6 (wild t …
Women Have Greater Endothelin-B Receptor Function and Lower Mitochondrial Capacity Compared to Men With Type 1 Diabetes.
Derella CC, Thomas J, Harris RA. Derella CC, et al. J Clin Endocrinol Metab. 2023 Sep 18;108(10):2561-2568. doi: 10.1210/clinem/dgad189. J Clin Endocrinol Metab. 2023. PMID: 37009678 Free PMC article.
CONTEXT: Type 1 diabetes (T1D) negatively affects both the endothelin system and muscle oxidative capacity. ...
CONTEXT: Type 1 diabetes (T1D) negatively affects both the endothelin system and muscle oxidative capacity. ...
Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis.
Lenoir O, Milon M, Virsolvy A, Hénique C, Schmitt A, Massé JM, Kotelevtsev Y, Yanagisawa M, Webb DJ, Richard S, Tharaux PL. Lenoir O, et al. J Am Soc Nephrol. 2014 May;25(5):1050-62. doi: 10.1681/ASN.2013020195. Epub 2014 Apr 10. J Am Soc Nephrol. 2014. PMID: 24722437 Free PMC article.
We then generated mice with a podocyte-specific double deletion of ETAR and ETBR (NPHS2-CreEdnra(lox/lox)Ednrb(lox/lox) [Pod-ETRKO]). In vitro, treatment with endothelin-1 increased total beta-catenin and phospho-NF-kappaB expression in wild-type glomeruli, but this effect …
We then generated mice with a podocyte-specific double deletion of ETAR and ETBR (NPHS2-CreEdnra(lox/lox)Ednrb(lox/lox) [Pod-ETRKO]). …
Intrarenal activation of endothelin type B receptors improves kidney oxygenation in type 1 diabetic rats.
Franzén S, Pihl L, Fasching A, Palm F. Franzén S, et al. Am J Physiol Renal Physiol. 2018 Mar 1;314(3):F439-F444. doi: 10.1152/ajprenal.00498.2017. Epub 2017 Nov 1. Am J Physiol Renal Physiol. 2018. PMID: 29092848 Free article.
About one-third of patients with type 1 diabetes develops kidney disease. The mechanism is largely unknown, but intrarenal hypoxia has been proposed as a unifying mechanism for chronic kidney disease, including diabetic nephropathy. ...Intrarenal activation of ETB-R improv …
About one-third of patients with type 1 diabetes develops kidney disease. The mechanism is largely unknown, but intrarenal hypoxia ha …